Molecular Formula | C27H38O3 |
Molar Mass | 410.6 |
Density | 1.11 |
Boling Point | 527.3±50.0 °C(Predicted) |
Appearance | Powder |
Storage Condition | 2-8℃ |
introduction | baodanone cyclovalpropionate (Boldenone Cypionate), abbreviated as Bc, is an androgen anabolic steroid and one of the esters of baodanone. Bordanone cyclopentanate is one of the most common anabolic androgen steroids used by bodybuilders and athletes for non-medical reasons in recent years. |
Application | Baodanone can be made into different forms of esters. Although the basic drug Baodanone is the same, the ester attached to it can change the metabolism of Baodanone in vivo. Anabolic androgen steroids are often esterified to prolong the duration of action of the hormone by intramuscular or subcutaneous injection. Longer ester chains will have a longer half-life, so the esterified bordanone will have a half-life of several hours, while the bordanone cyclopentanpropionate half-life will reach several weeks. |
synthesis | a high-yield synthesis method of baodan ketone, using ester formed by acid chloride and methanol as protective agent, and selecting a better catalyst, as follows: 1. etherification reaction: in a reaction kettle equipped with stirring, adding anhydrous ethanol, triethyl orthoformate, and then under the condition of stirring, 1.4?ADD, stirring for 5 minutes; Adjust the temperature in the reaction kettle to 39~42 ℃, then add pyridine bromide, react for 8 hours, add triethylamine, cool to 0~5 ℃, keep warm and stir for 1 hour. When the reaction solution reaches neutrality, it is frozen and crystallized at 0±2 ℃. The resulting etherate is slightly washed with anhydrous ethanol and filtered to obtain a wet etherate. The weight ratio of absolute ethanol, triethyl orthoformate, 1.4?ADD, pyridine bromohydride and triethylamine is 60-65:40-45:60-80:0.1-0.5:0.5-1.5; the weight ratio of absolute ethanol for the etherate obtained by slightly washing to the etherate obtained is 70-80:90-100. 2. reductive hydrolysis reaction: in the reaction pot, first add methanol, start stirring, then add ether, pyridine, cool to -2~2 ℃; Add sodium borohydride under stirring, put in within 1 hour, react at -2~2 ℃ for 1 hour, and do thin plate chromatography; After the reduction reaction is over, adjust the temperature to 10±5 ℃, add 36% hydrochloric acid, adjust PH to about 2.0, concentrate to concentrated slurry, flush with 350 ~ 400L of water, and cool to 0~5 ℃; Centrifuge to obtain reduced hydrolysate, namely crude Baodanone, and dry. The weight ratio of methanol, etheride, sodium borohydride, hydrochloric acid and water is 65~70:7~8:0.5~1:5~10:35~40; The dripping acceleration of hydrochloric acid shall be subject to no explosion and boiling of the material, and the temperature shall not exceed 20 ℃. After the dripping of hydrochloric acid is completed, the temperature shall be adjusted to 10~20 ℃, and the temperature shall be kept for 1 hour. 3. Refining of crude products: Put Baodanone crude products, methanol and water into the reaction kettle; Steam heating, reflux for 1 hour, cooling to 0~5 ℃, centrifugation. The weight ratio of Baodanone, methanol and water is 60~65:95~105:35~45. Baodanone can be further reacted with Baodanone cyclovalpropionate. |
biological activity | Boldenone Cypionate is an androgen anabolic steroid. |